As a youngster, it was usually one of the local TV shows that featured cartoons and local hosts/guests.
In college it was an early Japanese anime show called "Starblazers." It came on at 4pm, and on Fridays we'd often be suitably fortified in time to watch that afternoon's episode. I wish I had video of us, a group of drunk/stoned engineering students giggling our asses off as watched a reclaimed WWII Japanese battleship flying through space and fighting the evil Gamilons. That's quality entertainment right there.