I would not move now that I am hoping to retire soon and have a house close to a lot of my family.
The first time I moved to a town where I knew no one was when my kids were 5 and 8. Actually it was a few days before my youngest daughter's 6th birthday. My cousin lived in a town about 40 miles away and my mother's childhood friend lived in a town about 20 miles away and they were the only people I knew in the area. I had to have a better job and was not finding any one in the area I lived in before the move. I lived there for 3 years, during which my mother got a job in that town for one school year and later my uncle got a job in that town and he and my aunt moved across the street and down a few houses from me. So eventually I did have relatives and I made a few friends, one that I am still in touch with.
The reason I only stayed 3 years was because the town was crazy. The job was great and I liked my co-workers but I did not fit in that town. My younger daughter came home from school in second grade and said something that made me realize I did not want the influences of the people in that town over shadowing what I believed (it was a racist comment). In fact, the neighbor across the street came over one saturday in a tizzy because she found out that the very nice man that she thought was her "friend's" yard man, was actually the woman's husband. She was the only one who didn't realize that and she had coffee with the woman every weekday morning after the kids went to school. I asked her why she thought the man kept his car in her driveway (his driveway) and she said she though he didn't have a place to keep it. Amazing how racists (or anyone) can ignore very obvious clues because it doesn't fit with their view of who people are.
Anyway, when my youngest was in high school I moved from home again to Dallas, Tx for the same reason, needed a better paying job. I loved that area and the job except for the 11 hour drive to visit family. I was there 12 years and when my mother got sick I moved back home to take care of her. After she died I went back to that area for a job but at that point I was paying for my mother's house and paying rent so I asked if I could work remotely and they said yes. Sometimes moving to someplace where you don't know anyone is a good thing, and even if it isn't there is something to learn about the world and about yourself.