The big thing that just wiped out all of the native Americans North, Central, and, South was that the Europeans carried all manner of diseases that the Americans had absolutely no ability to deal with. In the case of many of the North American natives, a lot of the deaths that were attributed to smallpox may have actually been from Chicken Pox. They had no resistance to it and it just would eat them alive. To the Europeans, it LOOKED like smallpox but may not have been. Disease totally wiped out the natives of the Caribbean, but they did give something to the Europeans…Syphilis was unknown until it was brought back from the new world.